The commode had to be moved into the bedroom though she barely made it that far without accident. Day two she was angry staring up at the ceiling all day in bed, refused to eat or do anything.She was clearly agitated, confused, and bowel incontinence became a permanent feature Day one of the change to SSRI was a confusion day.Suddenly changes took place at a drastic pace: Thus it is no surprise, in retrospect, that we saw changes slowly from Mirtazapine but very fast changes as my mother was moved to take an SSRI. Serotonin is a dangerous substance that predisposes the patient to diabetes 2. Serotonin also functions as part of memory and cognition, and it is also a vasoconstrictor. The intestinal tract uses most of the serotonin to pass the food through the intestines with proper speed-this explains why having too much serotonin in one’s body causes bowel incontinence. Only a small percentage of serotonin is made in the brain, less than 10%, and 90% is in other parts of the body. This makes the brain cell manufacture serotonin forever, regardless how much is needed and how much it already has made. Just as your sink will flood your house with water if the overflow is plugged up, so does the brain fill up with serotonin as long as the reuptake is inhibited. However, SSRIs inhibit the reuptake receptor, i.e. If it senses that enough serotonin was made, it shuts down serotonin manufacturing of the cell until it senses that more is needed. This little overflow hole in the brain cell is called reuptake.
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This will allow the extra water to flow back into the drain and if you have an automated sink that is connected to this backflow, the sink would know it is full and would turn the faucet off. To understand what SSRIs do, envision a sink with an overflow hole on the top, in case you left the water running. While Mirtazapine merely provided a small extra dose of serotonin to the brain, Zoloft forced her brain to make serotonin 24/7. Then one day as I was refilling her medicine, the drugstore ran out of Mirtazapine and they placed her on an SSRI called Zoloft instead-the doctor changed her prescription.Īn SSRI (Selective Serotonin Reuptake Inhibitor) is a very different medicine from the old small dose serotonin my mother received. What I have just described took four years to evolve so we did not see the connection of all these changes to the serotonin medicine. She became very easy to irritate and was pissed at the whole world. Then bowel incontinence started and she had trouble holding her stool until she reached the bathroom her bowel incontinence further limited where she dared going so she felt angrier. The first sign that she had too much serotonin in her brain was that rather than feeling calmer and happier she became more agitated she was unhappy with people around her, criticized everything, nothing was good enough. In retrospect, we see what happened – hindsight is always 20/20. As she started taking the medicine, very tiny changes developed in her personality but they were so mild as to almost unnoticeable. The neurologist prescribed half of the smallest possible dose of Mirtazapine, a simple serotonin that on its own is capable causing major damage but she received a very small dose. She paid a visit to a neurologist begging for an antidepressant. I would rather say she was angry with life for what happened to her rather than depressed but she insisted that she was depressed. She was also dependent on others and became depressed. While her ankle was healing she was in bed and could not play bridge, she lost her skills and partner. She was restricted to bed for 6 months and then to wheelchair for life. The ankle that broke needed surgery with plates and screws. When they asked how old she was, her partners and competitors just flipped that she was in her 80s and a bridge champion. She even joined online bridge groups and beat everyone on the internet too. She had been extremely active, playing table tennis regularly in a senior club she was also a bridge champion almost all her life. My mother, then about 84 years old, broke her ankle. It started very slowly at an almost non-existent rate.